Van de Ven Double Ends The Toffees' Run at New Stadium
Micky van de Ven emerged as the initial defender to score twice in a Premier League match for Spurs since the Belgian defender in March 2013.
Key points
The Spurs defender heads into the net twice in opening period
The home side's defender has equalizer disallowed after VAR review
Senegalese midfielder scores third in 89th minute
The defeat is the Merseyside club's first at Hill Dickinson Stadium
Micky van de Ven found the net twice as Spurs prolonged their winning streak in away games in the Premier League and delivered Everton their initial loss at Hill Dickinson Stadium.
Everton were unbeaten in their last five matches at their new ground at the dockside location, having departed Goodison Park behind after more than a century at the conclusion of the previous campaign.
But Tottenham's leader Van de Ven struck on two occasions from corners in the first half to put their impressive record at risk, and they were failed to turn it around before the midfielder - assisted by ex-Everton forward Richarlison - nodded in a final goal to put the game to bed.
The Everton defender thought he had equalized the tally a short while after the defender's first goal, directing a bullet header past the Spurs keeper from an Everton corner.
The Portuguese striker, meanwhile, missed a handful of opportunities, while Vicario made a succession of excellent stops to guarantee Tottenham went five matches on the road unbeaten in the English top flight.
But the video assistant referee stepped in, advising the match official to review the goal on the pitchside monitor and the official decided that Jack Grealish and Iliman Ndiaye were in offside positions and had impeded with the Tottenham goalkeeper.
The win elevates the manager's side into third place in the division, five points off local foes and leaders Arsenal.
Everton stay 14th and are six points ahead of the relegation zone.
Spurs breakdown: The defender excels in role at each end of the field
After a drab weekday performance in the European competition against the French side, where they managed a only attempts on target, Frank chose the French striker up front instead of ex-Everton forward the Brazilian.
The new arrival was failed to make much of an impact before being replaced for Richarlison after an hour on the pitch, but it turns out he wasn't needed in the end.
Defender Van de Ven converted into an offensive threat to be feared.
Tottenham's first goal came from a cleverly executed corner routine, with Rodrigo Bentancur heading the ball back across the face of goal for an free the defender to score.
And Ven de Ven - stepping up as skipper in the Argentine's absence - notched his next goal in first-half stoppage time as he rose above the England keeper to nod in.
Van de Ven was equally impressive in defence, combining well with his defensive colleague as the pair dealt superbly with the numerous deliveries thrown their way by the opposition.
Everton analysis: Everton missing striker's instinct
Everton's recent stadium had been a fortress, but it appears the freshness may have worn off slightly and fans flocked to the gates after the midfielder's third for Spurs.
The end in the team's winning streak at home won't be a massive worry for the manager, but their striker situation will be.
Beto and Thierno Barry - the Toffees' pair of recognised centre-forwards - had scored only one league goal between them before the weekend's outing.
And they were unable to add to that miserable record on a wet and gloomy night on in Liverpool.
The striker's form was summed up when he opted to bicycle-kick a clear chance from near the goal, even with having room and opportunity to reposition for a more conventional attempt that would have tested Vicario.
Barry, as well, failed to influence the game after replacing the starter in the second half.
It was not for a shortage of opportunity. The majority of the home side's attacks came through the winger and the forward, who relentlessly delivered dangerous balls into the Tottenham penalty area.
What next for both teams?
The Toffees: Moyes' men travel to the Stadium of Light in the top flight on early November at 20:00 GMT.
Spurs: The London club go to St James' Park on Wednesday, 29 October for their next round League Cup tie against Newcastle.