Fresh analysis suggests that individuals who discontinue popular slimming jabs like Mounjaro or Wegovy can put back on lost weight much more quickly than those who end conventional diet and exercise regimens.
Findings released in a leading health publication demonstrates that while obese individuals frequently drop substantial amounts of their body weight while using the jabs, the weight is regained at an estimated rate of nearly a kilo each month upon discontinuation.
"Users using such drugs must be informed of the danger of quick weight regain when the medication ends," stated lead investigator Dr. Susan Jebb.
Such speed of regain means a reversion to original mass within about a year and a half.
Comparing Treatments
The research, which reviewed 37 of trials involving thousands of patients, contrasted the outcomes of the injectable medications with other pills.
Scientists note that people who shed pounds through lifestyle changes alone typically see a slower weight regain—approximately 100 grams monthly—after stopping.
The Reason for the Rapid Regain
Nutrition scientists suggest the mode of action of the injections is key to understanding the heightened regain.
These medications copy a body's own chemical called GLP-1, which controls hunger.
"Artificially providing GLP-1 levels several times higher than normal may cause the system to generate a reduced amount of its own natural hormone, and may also diminish sensitivity to its actions," explained Dr. Adam Collins, a nutrition researcher.
"Stopping of this medication means appetite is uncontrolled, making excessive eating a significant risk."
A Chronic Disease?
The NHS advise the injections for people with obesity-related medical conditions, alongside prescribed lifestyle changes.
Professionals argue that, given the high risk of relapse, the therapy should be considered long-term.
This view is reinforced by pharmaceutical companies, who state that the results "highlight the persistent character of obesity," akin to managing conditions like diabetes.
Patient Experiences
Users who have stopped the medication explain a intense return of hunger.
"It was like something flipping and you're instantly extremely hungry," recalled an individual.
The struggle is compounded if patients have not adopted lasting lifestyle or habit changes during treatment.
Growing Interest
Recent estimates show that a significant number of people in the UK have tried weight-loss jabs in the last 12 months, with interest being substantial.
- Use is greater among females compared to men.
- The middle-aged age group shows the greatest level of interest.
- Many access the drugs through private prescriptions rather than public health services.
In conclusion, clinicians stress that while these medications are potent tools for weight loss, they are not a permanent cure and long-term success hinges on ongoing behavioural changes.
